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| Mai, Tepoerau; Toullec, Jordan; Van Wynsberge, Simon; Besson, Marc; Soulet, Stephanie; Petek, Sylvain; Aliotti, Emmanuelle; Ekins, Merrick; Hall, Kathryn; Erpenbeck, Dirk; Lecchini, David; Beniddir, Mehdi A.; Saulnier, Denis; Debitus, Cecile. |
| Marine natural products isolated from the sponge Fascaplysinopsis cf reticulata, in French Polynesia, were investigated as an alternative to antibiotics to control pathogens in aquaculture. The overuse of antibiotics in aquaculture is largely considered to be an environmental pollution, because it supports the transfer of antibiotic resistance genes within the aquatic environment. One environmentally friendly alternative to antibiotics is the use of quorum sensing inhibitors (QSIs). Quorum sensing (QS) is a regulatory mechanism in bacteria which control virulence factors through the secretion of autoinducers (AIs), such as acyl-homoserine lactone (AHL) in gram-negative bacteria. Vibrio harveyi QS is controlled through three parallel pathways: HAI-1, AI-2,... |
| Tipo: Text |
Palavras-chave: Porifera; Marine natural products; Quorum sensing inhibitors; Antibiotic; Fascaplysinopsis cf reticulata. |
| Ano: 2019 |
URL: https://archimer.ifremer.fr/doc/00598/71052/69366.pdf |
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| Mai, T.; Tintillier, Florent; Lucasson, Aude; Moriou, C.; Bonno, E.; Petek, S.; Magre, Kevin; Al Mourabit, A.; Saulnier, Denis; Debitus, C.. |
| Sponges are a rich source for investigation of bioactive small molecules. They have been mostly investigated for the search of new pharmacological models or therapeutic agents for the treatment of human diseases. Micro-organisms can also represent a virulent pathogen for marine invertebrates such as sponges, which need to protect themselves against these microbes. Sponges' self defence mechanisms involving dialogue molecules thus represent a pertinent research track for potent anti-infective and anti-biofilm activities such as quorum sensing inhibitors (QSIs). The investigation of the QSI crude extract of Leucetta chagosensis Dendy, 1863 led to the isolation of three new alkaloids, isonaamine D, di-isonaamidine A and leucettamine D, along with the known... |
| Tipo: Text |
Palavras-chave: Biofouling; Leucetta chagosensis; Leucettamine; Naamidine; Naamine; Quorum sensing; Quorum sensing inhibitors; Sponges; Vibrio harveyi. |
| Ano: 2015 |
URL: http://archimer.ifremer.fr/doc/00275/38597/37189.pdf |
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